What Are Endocannabinoids?

Endocannabinoids are signaling molecules that the body makes itself, these molecules regulate the ECS.

Cannabinoids can also be found in nature, just like you find THC & CBD in weed and other herbs. The structure of these molecules corresponds to our own endocannabinoids, which is why these cannabinoid receptors bind & influence.

To investigate

Researchers have identified 2 major endocannabinoids so far:

Anandamide (AEA)
2-arachidonoylglycerol (2-AG)

Through their action on cannabinoid receptors, these molecules influence various processes. Think of the mood, sleep, appetite, memory and learning ability. However, each cannabinoid stimulates the ECS to varying degrees.

These molecules influence different processes through the action of the AEA & 2-AG.

Research has shown that AEA is an agonist with low activity on the CB1 and CB2 receptors. This means that the molecule elicits a small part of a response at these receptor sites. However, other studies showed that 2-AG is a full agonist of CB1 and CB2 receptors! This means that the endocannabinoid that binds together is very effective at both locations & thus promotes activation.

Both cannabinoids act on locations outside the ECS, the AEA ensures binding to TRPV1 receptors, which are often involved in pain & inflammation.

2-AG molecules play an important role in the brain, liver & lungs.

The main source of use for these molecules is for the supply of arachidonic acid. This is necessary in the synthesis of prostaglandin. These in turn have an important role in inflammation, blood flow & blood clotting.

How do endocannabinoids develop?

The development of these endocannabinoids takes place on the basis of demand in the membranes of postysynaptic neutrons. Here they are distinguished from other neutrotransmitters in that they remain in synaptic vesicles until they are actually needed.

AEA & 2-AG are derived from fat-based molecules, AEA is derived from the N-arachidonoyl-phosphatidyl-ethanol; 2-AG is derived from 2-arachidonoyl containing phospholipids (PIP).

After attaching to the appropriate receptor sites, they are both degraded in high acceleration by certain enzymes. The enzyme fatty acid amide hydrolase breaks down the AEA.


Endocannabinoids have an important function within the ECS and the human body in general. Due to their ability to traverse the synaptic cleft, they are able to influence neurotransmitter release and maintain homeostasis. These molecules are deeply involved in many important physiological processes, from appetite and mood to sleep. Research is increasingly revealing their extensive role in human physiology.

Endocannabinoids play a very important role within the ECS and the human body in general. Endocannabinoids have a great function with the ability to traverse the synaptic cleft, as they are able to influence the release of neurotransmitters and maintain the homeostate!

These molecules are very involved in many important physiological processes, from your appetite and mood to sleep. Research is increasingly showing about its extensive role in human physiology

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